Yu C,Wang Y,Li G,She L,Zhang D,Chen X,Zhang X,Qin Z,Cao H,Liu Y, 452. CD24 regulates sorafenib resistance via activating autophagy in hepatocellular carcinoma. Jia D, Duan F, Peng P, Sun L, Liu X, Wang L, Wu W, Ruan Y, Gu J. Lock M, Alvira M, Vandenberghe LH, Samanta A, Toelen J, Debyser Z, et al. Transcriptional regulation of Runx2 by HSP90 controls osteosarcoma apoptosis via the AKT/GSK-3/-catenin signaling. Yu Jiangyong;Zhao Shuangtao;Su Zhe;Song Chengli;Wu Lihong; Liu Qian;Qu Yuan;Wang Kai;Wu Runye;Zhang Ye;Huang Xiaodong;Zhang Jianghu;Chen Xuesong; Volume 12, Issue , 2022, PP 793351-793351. TRIM44 Promotes Colorectal Cancer Proliferation, Migration, and Invasion Through the Akt/mTOR Signaling Pathway. Yujun Rao,Yuxuan Fang,Wei Tan,Dan Liu,Yubin Pang,Xia Wu,Chunwang Zhang,Guoqing Li, 1377. Inhibition of HDAC3 Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice In Vivo and In Vitro. adenovirus), the capsid proteins, as well as the nucleic acid sequence delivered, can trigger the various components of our immune system. 187. Shi H,Bi H,Sun X,Dong H,Jiang Y,Mu H,Li W,Liu G,Gao R,Su J, 444. Cell entry occurs primarily by endocytosis but other entry mechanisms also exist. Chen L, Hu P, Zhang L, Huang S, Luo L, Huang C. 83. Although cationic liposomes have been widely used as an alternative for gene delivery vectors, a dose dependent toxicity of cationic lipids were also observed which could limit their therapeutic usages.[14]. Knockdown of Nedd8conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells. Zhang J, Guo S, Li J, Bao W, Zhang P, Huang Y, Ling P, Wang Y, Zhao Q. Primary cilia respond to intermittent low-magnitude, high-frequency vibration and mediate vibration-induced effects in osteoblasts. LncRNA GAS6-AS2 facilitates tumor growth and metastasis of hepatocellular carcinoma by activating the PI3K/AKT/FoxO3a signaling pathway. Liu L,Qi X,Gui Y,Huo H,Yang X,Yang L, 894. -Hederin Induces Apoptosis of Esophageal Squamous Cell Carcinoma via an Oxidative and Mitochondrial-Dependent Pathway. KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo. Cancer-associated fibroblasts promote malignancy of gastric cancer cells via Nodal signalling. However, the robust stability of these vectors provides ample opportunities to attempt different routes of administration and specialized delivery strategies (Table3). Polypseudorotaxane functionalized magnetic nanoparticles as a dual responsive carrier for roxithromycin delivery. It is not yet possible to know how a particular design will function by just combining the best elements together based on published reports, therefore considerable trial and error will eventually be required for deciding on the final construct. Huang G, Ji S, Luo P, Zhang Y, Wang G, Zhu S, Xiao S, Xia Z. Cao S,Cong F,Tan M,Ding G,Liu J,Li L,Zhao Y,Liu S,Xiao Y, 592. In addition, these techniques have been employed to identify novel AAV variants with reduced sensitivities to neutralizing antibodies (NAbs) [5457]. Yang L, Zhou L, Zong X, Cao X, Ji X, Gu W, Zhang S. 127. Synthetic regulatory RNAs selectively suppress the progression of bladder cancer. Tension enhances cell proliferation and collagen synthesis by upregulating expressions of integrin v3 in human keloid-derived mesenchymal stem cells. Han Y, Guo XH, Zheng QF, Zhu YL, Fan YY, Zhang XY. Dong W,Lv H,Li C,Liu Y,Wang C,Lin J,Wang Y,Qian G,Guo K,Zhang Y, 416. He H, Yang T, Jia S, Zhang R, Tu P, Gao J, Yuan Y, Han W, Yu Y. Chang P,Zhang M,Zhang X,Li G,Hu H,Wu J,Wang X,Yang Z,Zhang J,Chen W,Ren M,Li X,Zhu M,Chen B,Yu J, 525. about navigating our updated article layout. 301. Yang Q,Deng Y,Xu Y,Ding N,Wang C,Zhao X,Lou X,Li Y,Zhao H,Fang X, 940. Yao P,Li Y,Shen W,Xu X,Zhu W,Yang X,Cao J,Xing C, 480. Traditional herbal medicine-derived sulforaphene promotes mitophagic cell death in lymphoma cells through CRM1-mediated p62/SQSTM1 accumulation and AMPK activation. Yuan J,Li P,Pan H,Li Y,Xu Q,Xu T,Ji X,Liu Y,Yao W,Han L,Ni C, 483. Mays LE, Wilson JM. 207. Ting Guo,Donglan Yuan,Wei Zhang,Dandan Zhu,Aifang Xiao,Guangyao Mao,Wenjuan Jiang,Mei Lin,Jun Wang, 1548. Lin Liu,Yingtong Xu,Hongmei Dai,Shan Tan,Xiao Mao,Zhiheng Chen, 1177. Fu K,Chen L,Miao L,Guo Y,Zhang W,Bai Y, 511. Upregulation of TCTP expression in human skin squamous cell carcinoma increases tumor cell viability throughanti-apoptotic action of the protein. Xiang Gu, Jun Zhang, Wen-Jing Xia, Pu-Hua Zhang, Chang-Chang Yin, Gao-Peng Guana, Huang Long. Downregulation of CUEDC2 prevents doxorubicininduced cardiotoxicity in H9c2 cells. MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Krppel-like factor 4. Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells. Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein-47 and collagentype I in rat hepatic stellate cells in vitro. 43. Cationic poly(amidoamine) dendrimers induced cyto-protective autophagy in hepatocellular carcinoma cells. Liu J,Chen X,Dou M,He H,Ju M,Ji S,Zhou J,Chen C,Zhang D,Miao C,Song Y. Guan H,Shang G,Cui Y,Liu J,Sun X,Cao W,Wang Y,Li Y, 749. Li S, Wang F, Qu Y, Chen X, Gao M, Yang J, Zhang D, Zhang N, Li W, Liu H. 267. Xirui Wang,Wengao Zhang,Gangfeng Yin, 1380. Wang Q, Shen L, Huang W, Song Y, Xiao L, Xu W, Liu Y. Cytotoxic effects of-carboline alkaloids on human gastric cancer SGC-7901 cells. , Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells. The Research Peptides Laboratory ensures through rigorous testing via High Performance Liquid Chromatography , that all our products are of 97% and up in purity. 17. Hai-Jun Hu,Xiu Liang,Hai-Lang Li,Chun-Ming Du,Jia-Li Hao,Huai-Yuan Wang,Jin-Fa Gu,Ai-Min Ni,Lan-Ying Sun,Jing Xiao,Jin-Qing Hu,Hao Yuan,Yan-Song Dai,Xiao-Ting Jin,Kang-Jian Zhang,Xin-Yuan Liu, 1479. Zhou X,Cheng Z,Chen H,Shi S,Wang X,Orang M,Zhao J, 499. S Zhang, X Zheng, Y Sun, Y Wang, Z Zhang. Xueliang Su,Bangjie Wang,Yehong Wang,Baochun Wang, 1094. Different functions of DEPTOR in modulating sensitivity to chemotherapy for esophagealsquamous cell carcinoma. Messenger RNA (mRNA) is a type of single-stranded ribonucleic acid that is transcribed from a strand of DNA, which carries the coding information for protein synthesis to be further transcribed and processed into functional proteins. Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy. Li Z,Li H,Zhao ZB,Zhu W,Feng PP,Zhu XW,Gong JP, 1011. Edaravone inhibits autophagy after neuronal oxygen-glucose deprivation/recovery injury. Zhou Y, Zhu Y, Fan X, Zhang C, Wang Y, Zhang L, Zhang H, Wen T, Zhang K, Huo X, Jiang X, Bu Y, Zhang Y. [24] Some of the benefits of inorganic vectors is in their storage stability, low manufacturing cost and often time, low immunogenicity, and resistance to microbial attack. Ying Qi,Qingqing Cui,Wenjing Zhang,Renjie Yao,Dong Xu,Fengyan Zhang, 1450. Wang T,Cheng J,Wang S,Wang X,Jiang H,Yang Y,Wang Y,Zhang C,Liang W,Feng H, 404. 51. Construction and analysis of compact muscle-specific promoters for AAV vectors. Ke Y,Zhang X,Liu C,Xiao M,Li H,Fan J,Fu P,Wang S,Zan F,Wu G, 769. Yu J,Jiang L,Gao Y,Sun Q,Liu B,Hu Y,Han X, 501. 90. Alloy-Type Lithium Anode Prepared by Laser Microcladding and Dealloying for Improved Cycling/Rate Performance. MIR210HG predicts poor prognosis and functions as an oncogenic lncRNA in hepatocellular carcinoma. Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygenspecies via targeting Akt/mTOR pathway. miR-1226-3p Promotes Sorafenib Sensitivity of Hepatocellular Carcinoma via Downregulation of DUSP4 Expression. An S, Gao Y, Huang Y, Jiang X, Ma K, Ling J. Exosomal microRNA-155-5p from PDLSCs regulated Th17/Treg balance by targeting sirtuin-1 in chronic periodontitis. Inhibition of YAP with siRNA prevents cartilage degradation and ameliorates osteoarthritis development. Protective potential of klotho protein on diabetic retinopathy: Evidence from clinical and in vitro studies. 977. Tian BP, Li F, Li R, Hu X, Lai TW, Lu J, Zhao Y, Du Y, Liang Z, Zhu C, Shao W, Li W, Chen ZH, Sun X, Chen X, Ying S, Ling D, Shen H. 558. Ao X,Yang Y,Li W,Tan Y,Guo W,Ao L,He X,Wu X,Xia J,Xu X,Guo J, 955. Combination of targeting CD24 and inhibiting autophagy suppresses the proliferation and enhances the apoptosis of colorectal cancer cells. Research efforts focusing on improving the efficiency of naked DNA uptake have yielded several novel methods, such as electroporation, sonoporation, and the use of a "gene gun", which shoots DNA coated gold particles into the cell using high pressure gas.[10]. Chlorogenic acid inhibits osteosarcoma carcinogenesis via suppressing the STAT3/Snail pathway. 3D porous chitosan scaffolds suit survival and neural differentiation of dental pulp stem cells. Uhrig S, Coutelle O, Wiehe T, Perabo L, Hallek M, Buning H. Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis. Liu J,Liu S,Deng X,Rao J,Huang K,Xu G,Wang X, 791. miR-145-5p Acts as a Novel Tumor Suppressor in Hepatocellular Carcinoma Through Targeting RAB18. Yongjuan Li,Xiaoyan Chen,Wei Xue,Junjun Liang,Liang Wang, 1348. Li R,Dong Z,Zhuang X,Liu R,Yan F,Chen Y,Gao X,Shi H, 992. Yang C, Wu D, Jia J, Liu D, Li Z, Zhang C, Li M, Xia Y. Xu ZZ, Xiu P, Lv JW, Wang FH, Dong XF, Liu F, Li T, Li J. The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells. Gao S,Song Q,Liu J,Zhang X,Ji X,Wang P, 795. Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines. Relationship between expression of XRCC1 and tumor proliferation, migration, invasion, and angiogenesis in glioma. Ma C,Wen B,Zhang Q,Shao PP,Gu W,Qu K,Shi Y,Wang B, 575. Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells. Bang-Yi Lin,Jia-Liang Wen,Chen Zheng,Li-Zhi Lin,Cheng-Ze Chen,Jin-Miao Qu, 1467. Huang Y,Zhou F,Xiao Y,Shen C,Liu K,Zhao B, 932. Lei Liu,Yuexiang Yan,Guanyu Zhang,Chengxue Chen,Weihong Shen,Peixiang Xing, 1221. Dang W,Wang X,Li J,Deng C,Liu Y,Yao Q,Wang L,Chang J,Wu C, 422. Xiaolong Yin,Yujun Liao,Weiwei Xiong,Yuezhi Zhang,Yue Zhou,Yang Yang, 1309. Shengli Li,Wenwen Guo,Huayun Geng,Chao Wang,Shuige Yang,Xinxin Xu, 1254. In genetic research, several ground-breaking findings have resulted not from candidate gene studies but through unbiased functional screening or selection of genetic libraries in cultured cells. Acceleration of skin regeneration in full-thickness burns by incorporation of bFGF-loadedalginate microspheres into a CMCS-PVA hydrogel. The antitumor effect of TAT-DCF1 peptide in glioma cells. Protective Effect of Total Phenolic Compounds from Inula helenium on Hydrogen Peroxide-induced OxidativeStress in SH-SY5Y Cells. Effects of ROCK inhibitor, Y-27632, on adhesion and mobility in esophageal squamous cell cancer cells. LncRNA H19 promotes the development of hepatitis B related hepatocellular carcinoma through regulating microRNA-22 via EMT pathway. Staphylococcus aureus supernatant induces the release of mouse -defensin-14 from osteoblasts via the p38MAPK and NF-B pathways. Cai D,Huff TW,Liu J,Yuan T,Wei Z,Qin J, 591. MiR-122-5p suppresses the proliferation, migration, and invasion of gastric cancer cells by targeting LYN. Liu QH,Yong HM,Zhuang QX,Zhang XP,Hou PF,Chen YS,Zhu MH,Bai J, 1211. Cai W, Dong F, Wang Z, Yang X, Zheng M, Che X. 92. [28] For guidance into mitochondria, a mitochondrial targeting sequence can be used; this method is used in protofection (a technique that allows for foreign mitochondrial DNA to be inserted into cells' mitochondria). Clement N, Knop DR, Byrne BJ. Selected AAV vectors, known receptors, and known tropisms, AAV adeno-associated virus, EGFR epidermal growth factor receptor, FGFR fibroblast growth factor receptor, G galactose, H heart, HGFR hepatocyte growth factor receptor, HS heparan sulfate, Lg lung, LR laminin receptor, Lv liver, N neuronal, P pancreas, PDGFR platelet-derived growth factor receptor, PR photoreceptors, RPE retinal pigmented epithelia, SA sialic acid, Sk skeletal muscle. 187. Ma GF, Chen SY, Sun ZR, Miao Q, Liu YM, Zeng XQ, Luo TC, Ma LL, Lian JJ, Song DL. Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells. It is involved in cartilage development. Xu J,Wang H,Wang H,Chen Q,Zhang L,Song C,Zhou Q,Hong Y, 683. Lu Yang,Hongwei Sun,Xing Liu,Jinxin Chen,Zhimin Tian,Jia Xu,Bowen Xiang,Baoli Qin, 1099. miR-429 mediates tumor growth and metastasis in colorectal cancer. Qiaoli Chen,Xiaoye Li,Lingjun Kong,Qing Xu,Zi Wang,Qianzhou Lv, 1147. Bei K, Du Z, Xiong Y, Liao J, Su B, Wu L. 78. 65. (IF 2.984) 504. Clusterin ameliorates endothelial dysfunction in diabetes by suppressing mitochondrial fragmentation. Inducible HSP70 antagonizes IL-1 cytocidal effects through inhibiting NF-kB activation via destabilizing TAK1 inHeLa cells. Wu Z, Asokan A, Samulski RJ. Esculetin regulates the phenotype switching of airway smooth muscle cells. Classical Swine Fever Virus Infection and Its NS4A Protein Expression Induce IL-8 Production through MAVS Signaling Pathway in Swine Umbilical Vein Endothelial Cells. Toxicity of graphene oxide and multi-walled carbon nanotubes against human cells and zebrafish. Although not optimal, it is possible to prescreen subjects for the presence of NAbs to the particular AAV variant to be used. Xin Peng,Cong Zhang,Jun-Ping Bao,Lei Zhu,Rui Shi,Zhi-Yang Xie,Feng Wang,Kun Wang,Xiao-Tao Wu, 1295. Han Y, Wu Z, Wu T, Huang Y, Cheng Z, Li X, Sun T, Xie X, Zhou Y, Du Z. Xiaohan Chang,Huijie Zhang,Qing Yang,Li Pang, 1298. Although there is much known about these individual components that needs to be considered when designing an AAV vector, the final design will most likely need to be determined empirically. The transfer construct carries the gene to be transduced or "transgene". Huang N, Lin J, Ruan J, Su N, Qing R, Liu F, He B, Lv C, Zheng D, Luo R. 56. Yu S,Zhang Y,Li Q,Zhang Z,Zhao G,Xu J, 1052. Miao S, Sun L, Wang P, Liu R, Su Z, Zhang S. 84. 387. SIRT4 silencing in tumor-associated macrophages promotes HCC development via PPAR signalling-mediated alternative activation of macrophages. 194. TAZ sensitizes EGFR wild-type non-small-cell lung cancer to gefitinib by promoting amphiregulin transcription. Xiao YX, Shen HQ, She ZY, Sheng L, Chen QQ, Chu YL, Tan FQ, Yang WX. Shi W, Nie D, Jin G, Chen W, Xia L, Wu X, Su X, Xu X, Ni L, Zhang X, Zhang X, Chen J. Retroviruses have limited natural host cell ranges, and although adenovirus and adeno-associated virus are able to infect a relatively broader range of cells efficiently, some cell types are resistant to infection by these viruses as well. Lu Yang,Hongwei Sun,Xing Liu,Jinxin Chen,Zhimin Tian,Jia Xu,Bowen Xiang,Baoli Qin, 1099. Effects of different sustained hydrostatic pressures on connexin 43 in human bladder smooth muscle cells. Chao Zhou,Pu Wang,Mengtian Tu,Yi Huang,Fei Xiong,Yue Wu, 1248. With regard to the gene of interest, codon engineering to support maximal, tissue-specific expression should be performed. Liwei Zhang,Xiaohua Chang,Tingting Zhai,Jing Yu,Wenbin Wang,Aiping Du,Na Liu, 1242. BMP Known functions Gene Locus BMP1 *BMP1 does not belong to the TGF- family of proteins.It is a metalloprotease that acts on procollagen I, II, and III. Long noncoding RNA MIR31HG abrogates the availability of tumor suppressor microRNA-361 for the growth of osteosarcoma. Influence mechanism of miRNA-144 on proliferation and apoptosis of osteosarcoma cells. 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